Benzo-fused heterocyclic anti-ulcer agents

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 275/04 (2006.01) C07D 209/46 (2006.01) C07D 209/50 (2006.01) C07D 275/06 (2006.01) C07D 277/04 (2006.01) C07D 295/096 (2006.01) C07D 307/52 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1185970

ABSTRACT OF THE DISCLOSURE Compounds having the formula: Image wherein R is hydrogen, mono- or dihalo, amino, nitro, cyano, hydroxy, trifluoromethyl, mercapto, lower alkyl, lower alkoxy, alkanoyl, lowercycloalkyl carboxy, alkoxycarbonyl, mono- or di-lower alkyl substituted amino, alkanoylamino, lower alkyl thio, loweralkylsulfonyl, sulfamoyl, lower alkyl substituted sulfumoyl, phenyl or phenyl substituted with halo, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, amino, cyano or nitro; X is SO2, SO, S or C=O; and A is an amine selected from the group: Image wherein R1 is hydrogen or R2CH2 wherein R2 is mono- or dilower- alkylamino, mono- or di-N-lower alkylaminolower-alkyl, (2- furyl)methylamino, benzylamino, lowercycloalkylamino, 1-pyrroli- dinyl, 1-piperidinyl, 1-hexahydroazepinyl, 1-octahydroazocinyl, 3-thiazolidinyl, 4-morpholinyl or 4-thiomorpholinyl; R3 is hydrogen or (1-piperidinyl)methyl with the proviso that when R3 is (1-piperidinyl)methyl, R1 is hydrogen; n is 1 to 4, and the pharmacologically acceptable salts thereof, have a selective action on H2 histamine receptors and which inhibit gastric acid secretion.

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