Benzo-fused heterocyclic compounds with a 5-membered ring,...

Details Benzo-fused heterocyclic compounds with a 5-membered ring,... Benzo-fused heterocyclic compounds with a 5-membered ring,...

C - Chemistry, Metallurgy

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C07D 209/42 (2006.01) A61K 31/33 (2006.01) C07D 235/06 (2006.01) C07D 235/32 (2006.01) C07D 249/18 (2006.01) C07D 277/68 (2006.01) C07D 307/84 (2006.01) C07D 307/85 (2006.01) C07D 307/86 (2006.01) C07D 333/70 (2006.01) C07D 401/04 (2006.01) C07D 403/12 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2129301

HOECHST AKTIENGESELLSCHAFT - HOE 93/F 223 K Dr.VF/we Abstract Benzo-fused heterocyclic compounds having a 5-membered ring, processes for their preparation, their use as medicaments, their use as diagnostic agents and medica- ments containing them Benzo-fused heterocyclic compounds having a 5-membered ring, of the formula I Image (I) where X is N or CR(6); Y is oxygen, S or NR(7); A and B together are a bond or are both hydrogen, if, at the same time, X is CR(6) and Y is NR(7), one of the substituents R(1) to R(6) is a -CO-N=C(NR2)2 group; the other respective substituents R(1) to R(6) are H, Hal or alkyl; up to two of the other substituents R(1) to R(6) are CN, N02, N3, (C1-C4)-alkoxy, CF3; up to one of the other substituents is R(8)-CnH2n-Z- or phenyl; R(7) is H, alk(en)yl or R(8)-CnH2n-, and pharmaceutically tolerated salts thereof, are described. A process for the preparation of the compounds I which comprises reacting a compound of the formula II Image (II) in which one of the substituents R(1)' to R(5)' is a -CO-L group and L is a leaving group which can easily be replaced nucleophilically, with guanidine, and, if appropriate, converting the product into the pharmaco- logically tolerated salt, furthermore is also described.

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