Benzo(ij)quinolizine-2-carboxylic acid compounds,...

C - Chemistry – Metallurgy – 07 – D

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260/266.3

C07D 455/04 (2006.01)

Patent

CA 1156232

ABSTRACT OF THE DISCLOSURE A benzo[ij]quinolizine-2-carboxylic acid compound, a composition containing the compound, and processes for production of the compound are described; the compound is Image (I) wherein R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a halogen atom; R3 represents a lower alkyl group substituted with one or more of a halogen atom and a hydroxy group, a lower alkanoyl group substituted with one or more halogen atoms, a phenylalkyl group substituted with one or more lower alkoxy groups on the phenyl ring, a lower alkanesulfonyl group substituted with one or more halogen atoms, a lower alkenyl group or a lower alkynyl group; or a pharmaceu- tically acceptable salt thereof. The compounds have an antimicrobial activity, and are particularly effective on those bacteria resistant to conventional antibiotics and can be maintained at high concentration levels in blood for extended periods of time.

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