Benzo¬ij|quinolizine-2-carboxylic acid derivatives

Details Benzo¬ij|quinolizine-2-carboxylic acid derivatives Benzo¬ij|quinolizine-2-carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

260/266.3

C07D 455/04 (2006.01)

Patent

CA 1253154

BENZO[ij]QUINOLIZINE-2-CARBOXYLIC ACID DERIVATIVES ABSTRACT OF THE DISCLOSURE Benzo[ij]quinolizine-2-carboxylic acid derivatives of the general formula [I] and the salts, and their hydrates are provided: Image [I] wherein A is a methylene group and B is a carbonyl group when A and B are linked by a single bond, or A and B unite together to form a vinylene group when A and B are linked by a double bond, R1 is a hydrogen atom, a C1-3 alkyl group or a 2-hydroxyethyl group, R2 and R3 are hydrogen atoms, methyl groups or ethyl groups and may be identical to or different from each other, R3 may be attached to the same carbon atom as R2, R4 is a methyl or ethyl group, and X is a halogen atom. The benzo[ij]quinolizine-2-carboxylic acid derivatives and the salts, and their hydrates have good absorbability from the digestive tract into the circulating blood and exhibit excellent and long-lasting antibacterial activity.

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