Benzo-(pyrano and thiopyrano)-¬3,4-b|pyridine compounds

Details Benzo-(pyrano and thiopyrano)-¬3,4-b|pyridine compounds Benzo-(pyrano and thiopyrano)-¬3,4-b|pyridine compounds

C - Chemistry, Metallurgy

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C07D 491/052 (2006.01) A61K 31/435 (2006.01) C07D 209/48 (2006.01) C07D 311/22 (2006.01) C07D 311/58 (2006.01) C07D 335/06 (2006.01) C07D 405/06 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1298582

4-14866/+/CGC 1083 Benzo-(Pyrano and Thiopyrano)-[3,4-b]Pyridine Compounds Abstract of the Disclosure Disclosed are the compounds of formula I, Image (I) wherein X represents oxygen or sulfur; ring A is unsubstituted or substituted by one to three identical or different substituents selected from hydroxy, hydroxy-C1-7-alkyl, etherified hydroxy, etherified hydroxy-C1-7-alkyl, acyloxy, acyloxy-C1-7-alkyl, halogen, C1-7-alkyl, trifluoromethyl, amino, mono- and di-C1-7-alkylamino and acylamino; or ring A is substituted by one C1-7-alkylenedioxy; R represents hydrogen, C1-7-alkyl or aryl-C1-7-alkyl; R1 represents hydrogen, C1-7-alkyl, C1-7-alkylthio-C1-7-alkyl, amino, acylamino, (amino, mono- or di-C1-7-alkylamino)-C1-7-alkyl, carboxy, C1-7- alkoxycarbonyl, carbamoyl or mono- or di-C1-7-alkylcarbamoyl; R2 to R5 represent hydrogen or C1-7-alkyl; the dehydro derivatives thereof with a double bond at the 1,2-position, or at the 1,10b-position in which case R5 is absent; salts, especially pharmaceutically acceptable salts thereof. They are useful as psychoactive agents for the treatment of central nervous system disorders. They may be prepared by cyclisation of a corresponding precursor in that the nitrogen containing ring is closed between said nitrogen and the 4a-carbon.

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