Benzoaxathiepin derivatives and their use as medicines

Details Benzoaxathiepin derivatives and their use as medicines Benzoaxathiepin derivatives and their use as medicines

C - Chemistry, Metallurgy

07

D

C07D 327/02 (2006.01) A61K 31/39 (2006.01) A61P 9/10 (2006.01) C07C 323/22 (2006.01)

Patent

CA 2441534

The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R¿1? and R¿2?, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hydroxy group, an alkyl, cyclopropyl, alkoxy, cyclopropoxy radical or when they occupy adjacent positions, form with the carbon atoms bearing them a carbon-containing cycle or an oxygen-containing heterocycle with five non-aromatic rings; R¿3? represents an alkyl radical, a hydroxy group or a methoxy radical; R¿4? represents a hydrogen atom or a methyl radical; and R¿5 ?and R¿6?, identical or different represent a hydrogen atom, an alkyl, alkoxy, alkylthio, alkylamino radical, or the groups OR¿4? and R¿5? form with the carbons which bear them a non-aromatic heterocycle with five or six rings containing at least an oxygen atom; and their pharmaceutically acceptable additions salts.

(voir formule ci-haut) Dérivés de la 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiépine de formule générale (1), formule (1) dans laquelle R1 et R2, identiques ou différents, représentent un atome d'hydrogène, un atome de fluor ou un atome de chlore, un groupe hydroxy, un radical alkyle, cyclopropyle, alcoxy, cyclopropoxy ou lorsqu'ils occupent des positions adjacentes, forment avec les atomes de carbone qui les portent un cycle carboné ou un hétérocycle oxygéné à cinq chaînons non aromatique; R3 représente un radical alkyle, un groupe hydroxy ou un radical méthoxy; R4 représente un atome d'hydrogène ou un radical méthyle et R5 et R6 identiques ou différents représentent un atome d'hydrogène, un radical alkyle, alcoxy, alkylthio, alkylamino, ou les groupes OR4 et R5 forment avec les carbones qui les portent un hétérocycle non aromatique à cinq ou six chaînons contenant au moins un atome d'oxygène, leurs sels d'addition pharmaceutiquement acceptables. La présente invention est utile, par exemple, pour le traitement de l'angor stable, l'angor instable, l'insuffisance cardiaque, le syndrome du QT long d'origine congénitale, l'infarctus du myocarde et les troubles du rythme cardiaque.

Affiliated with

Also associated with

Rating

Benzoaxathiepin derivatives and their use as medicines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzoaxathiepin derivatives and their use as medicines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzoaxathiepin derivatives and their use as medicines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1948613