Benzoazolypiperazine derivatives having vr1 antagonist activity

Details Benzoazolypiperazine derivatives having vr1 antagonist activity Benzoazolypiperazine derivatives having vr1 antagonist activity

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/495 (2006.01) A61P 13/00 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2511509

A compound of formula (I) wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a ~Benzoazolylpiperazine Compound~), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson~s disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, retricted brain function, Huntington~s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of Benzoazolylpiperazine Compound are disclosed.

L'invention concerne un composé de formule (I), dans laquelle Ar1, A, R3, x et m sont tels que définis dans la description et Ar2 est un groupe benzothiazolyle, benzooxazolyle ou benzoimidazolyle ou un sel pharmaceutiquement acceptable correspondant ("composé benzoazolylpipérazine"), des compositions comprenant un composé benzoazolylpipérazine, ainsi que des méthodes destinées à traiter ou prévenir la douleur, l'incontinence urinaire, un ulcère, la maladie intestinale inflammatoire, le syndrome du côlon irritable, un trouble addictif, la maladie de Parkinson, le parkinsonisme, l'anxiété, l'épilepsie, l'accident vasculaire cérébral, une crise, un état prurigineux, la psychose, un trouble cognitif, un déficit de la mémoire, la diminution de la fonction cérébrale, la chorée de Huntington, la sclérose latérale amyotrophique, la démence, la rétinopathie, un spasme musculaire, une migraine, le vomissement, la dyskinésie ou la dépression chez un animal. Cette méthode consiste à administrer une dose efficace d'un composé benzoazolylpipérazine à un animal nécessitant un tel traitement.

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