C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/16 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/10 (2006.01) C07F 7/08 (2006.01)
Patent
CA 2611530
The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention a trait à des composés de 5H-benzo[4,5]cyclohepta[1,2-b]pyridine, qui sont utiles pour le traitement de maladies proliférantes cellulaires, pour le traitement de troubles associés à l'activité du gène MET, et pour l'inhibition de récepteur tyrosine kinase MET. L'invention a également trait à des compositions comportant ces composés, et à leurs procédés d'utilisation pour le traitement du cancer chez des mammifères.
Dinsmore Christopher J.
Gabarda Ortega Ana Esther
Guerin David J.
Jewell James P.
Katz Jason D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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