Benzocycloheptene derivatives

Details Benzocycloheptene derivatives Benzocycloheptene derivatives

C - Chemistry, Metallurgy

07

C

167/246, 260/550

C07C 63/66 (2006.01) A61K 31/235 (2006.01) C07C 33/16 (2006.01) C07C 45/46 (2006.01) C07C 45/51 (2006.01) C07C 45/61 (2006.01) C07C 45/68 (2006.01) C07C 47/457 (2006.01) C07C 49/67 (2006.01) C07C 49/697 (2006.01) C07C 49/792 (2006.01) C07C 63/74 (2006.01) C07C 65/19 (2006.01) C07C 69/76 (2006.01)

Patent

CA 1298309

RAN 4060/145 Abstract Compounds of the general formula Image I wherein R1 signifies hydroxy, lower-alkoxy, amino, mono- or di-lower-alkylamino: R2 signifies hydrogen, alkyl, alkoxy or halogen; R3 , R4 , R5 , R6 , R11 and R12 each independently signify hydrogen or lower-alkyl; R3 and R together signify a methylene or hydroxy- methylene group; R7, R8, R9 and R10 signify hydrogen or lower- -alkyl; R11 and R12 together signify an oxo group or spiro- -cyclo-lower alkyl; or R11 signifies hydrogen and R12 signifies hydroxy or acetoxy: and one of the residues R13 and R14 signifies hydrogen and the other signifies lower-alkyl or trifluoromethyl, as well as physiologically compatible salts of carboxylic acids of formula I can be used as medicaments, especially for the treatment of neoplasms, acne and psoriasis. The novel compounds can be manufactured by the synthesis of the C(R13)=C(R14) double bond according to Wittig from a corresponding bicyclic component and a corresponding monocyclic component and optional subsequent transform- ation of functional groups.

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