Benzocycloheptenes, benzoxepines and benzothiepines

Details Benzocycloheptenes, benzoxepines and benzothiepines Benzocycloheptenes, benzoxepines and benzothiepines

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07C 57/58 (2006.01) C07C 59/66 (2006.01) C07C 323/20 (2006.01) C07D 213/30 (2006.01) C07D 213/57 (2006.01) C07D 213/89 (2006.01) C07D 215/60 (2006.01) C07D 217/14 (2006.01) C07D 239/26 (2006.01) C07D 409/04 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2129642

2129642 9413658 PCTABS00032 The subject of the invention is compounds of general formula (I), in which: X represents O or CHR; R1, R2, R3 and R4, which are identical or different, represent a hydrogen atom or a C1-C7 alkyl group, it being possible for R1 to additionally form a bond with R; R5 represents a hydrogen atom, a hydroxyl group or R5, taken together with R7, forms a bond or a $(1,3)$O group; R6 represents a group of formula (a) in which R10 and R11, taken together with the carbon atom to which they are attached, form a nitrogenous heterocyclic group, and their N-oxides and pharmaceutically acceptable salts. These compounds are powerful activators of potassium channels.

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