Benzodiazepine and benzopiperazine analog inhibitors of...

C - Chemistry – Metallurgy – 07 – D

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C07D 243/14 (2006.01) C07D 207/16 (2006.01) C07D 241/44 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2620414

This invention relates to compounds for the inhibition of histone deacetylase More particularly, the invention provides for compounds of formula (I): wherein A, B, D, E, X1, X2, X3, X4 and n are as defined in the specification A method of inhibiting histone deacetylase in a cell, the method comprising contacting the cell with a compound of formula (I), in an amount sufficient to inhibit histone deacetylase, is also disclosed.

La présente invention concerne des composés utilisés pour inhiber l'histone déacétylase et concerne plus particulièrement des composés représentés par la formule (I) dans laquelle A, B, D, E, X1, X2, X3, X4 et n sont tels que définis dans le descriptif. Cette invention se rapporte également à un procédé d'inhibition de l'histone déacétylase dans une cellule, ledit procédé consistant à mettre la cellule en contact avec un composé représenté par la formule (I), suivant une quantité suffisante pour inhiber l'histone déacétylase. Formule (I)

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