Benzodiazepine cgrp receptor antagonists

Details Benzodiazepine cgrp receptor antagonists Benzodiazepine cgrp receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/403 (2006.01) A61K 31/47 (2006.01) A61K 31/519 (2006.01) A61K 38/16 (2006.01) A61K 45/08 (2006.01)

Patent

CA 2529196

The present invention is directed to compounds of Formula I: I (where variables R1, R2, R3, R6, R7, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention concerne des composés de formule (I). Dans cette formule, les variables R?1¿, R?2¿, R?3¿, R?6¿, R?7¿, G, J, Q, T, U, V, W, X et Y sont définies dans la description. Ces composés sont utiles en tant qu'antagonistes des récepteurs du CGRP et utiles pour le traitement et pour la prévention de maladies dans lesquelles le CGRP est impliqué, notamment la céphalée, la migraine et la céphalée vasculaire de Horton. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions pour la prévention et pour le traitement de maladies dans lesquelles le CGRP est impliqué.

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