C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/5513 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2529227
The present invention is directed to compounds of Formula I: I (where variables R1, R2, R3, R6, R7, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
L'invention concerne des composés de formule (I). Dans cette formule, R?1¿, R?2¿, R?3¿, R?6¿, R?7¿, G, J, W, X et Y sont définis dans la description. Les composés de l'invention sont utiles en tant qu'antagonistes des récepteurs de CGRP, et sont utiles pour le traitement ou pour la prévention de maladies dans lesquelles le CGRP est impliqué, notamment les céphalées, les migraines, les céphalées vasculaires de Horton. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions dans la prévention et dans le traitement de maladies dans lesquelles le CGRP est impliqué.
Burgey Christopher S.
Stump Craig A.
Williams Theresa M.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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