Benzodiazepine compounds

Details Benzodiazepine compounds Benzodiazepine compounds

C - Chemistry, Metallurgy

07

D

260/239.4

C07D 487/04 (2006.01)

Patent

CA 1152985

ABSTRACT OF THE DISCLOSURE Novel 5,10,11,11a-tetrahydro-8-methyl-11-sulfo or sulfino-1H-pyrrolo[2,1-c][1,4]-benzodiazepin-2- acrylamides which have antitumor activity and low toxicity are prepared by reacting corresponding 11- reactive compound with a reactive sulfur compound to form 11-sulfino compounds and, if desired, oxidizing the 11-sulfino compounds to obtain 11-sulfo compound.

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