C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/239.5
C07D 487/04 (2006.01) C07D 231/38 (2006.01)
Patent
CA 1159056
ABSTRACT Compounds are described of the formula Image or an acid addition salt thereof; in which R1, R2, R3 and R4 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-4 alkyl, halogen, C1-4 haloalkyl, C1-4 alkanoyl, nitro, amino, C2-4 acylamino, cyano, hydroxyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkoxy or a group of the formula -SO2N(R8)2, -SO2R8, or -SO3R8 where R8 is C1-4 alkyl, C1-4 haloalkyl or optionally substituted phenyl; in which R5 is a group of the formula Image where R9 is hydrogen,C1-4 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C1-4 alkanoyl, benzyl, cyano or optionally substituted phenyl, where R10 is hydrogen, C1-4 alkyl or optionally substituted phenyl and where n is 0 or l; in which R6 is hydrogen, C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-4 alkyl, C1-4 haloalkyl, benzyl, C1-6 alkanoyl, C1-4 carbalkoxy or benzoyl; and in which R7 is one of the values of R6 or halogen, nitro, cyano, amino or C1-4 acylamino. The compounds have neuroleptic, sedative, relaxant, anxiolytic or anti-emetic properties, while at the same tine have low toxicity, and thus are useful in the treatment of disorders of the central nervous system.
362328
Chakrabarti Jiban K.
Hotten Terrence M.
Gowling Lafleur Henderson Llp
Lilly Industries Limited
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