Benzodiazepine compounds and their use as pharmaceuticals

Details Benzodiazepine compounds and their use as pharmaceuticals Benzodiazepine compounds and their use as pharmaceuticals

C - Chemistry, Metallurgy

07

D

167/210, 260/239

C07D 277/56 (2006.01) A61K 31/55 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1318669

BENZODIAZEPINE COMPOUNDS AND THEIR USE AS PHARMACEUTICALS ABSTRACT OF THE INVENTION Pharmaceutical thiazolo-[1,5]benzodiazepines of the formula Image in which R1, R2, R3 and R4 are independently hydrogen, C1-4 alkyl, C2-4 alkenyl, halogen, C1-4 haloalkyl, nitro, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio or phenylsulphonyl; in which R5 is a group of the formula formula Image where R7 is hydrogen, C1-6 alkyl, C3-7 cycloalkyl C1-4 alkyl, benzyl or ZO-C2-6 alkyl where Z is hydrogen or an acyl group, R8 is hydrogen or C1-4 alkyl and n is 0 or 1, provided that when R7 is hydrogen n is 0; in which R6 is hydrogen, C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or C1-4 alkylthio; and in which Image represents a thiazole ring selected from Image or Image ; and acid addition salts thereof. The compounds have central nervous system activity.

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