Benzodiazepine derivative for the treatment of hematopoietic...

A - Human Necessities – 61 – K

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A61K 31/5517 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2758473

A method and medicament for treating mixed lineage leukemia; translocated mixed lineage leukemia; translocated mixed lineage leukemia based acute myelogenous leukemia; translocated mixed lineage leukemia based acute lymphoid leukemia; a non-MLL based chronic myeloproliferative disorder, or non-MLL based acute lymphoid leukemia is provided, wherein the active agent used is the GSK-3 inhibitor 7-(2,5-dihydro-4-imidazo[ 1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9- fluoro- 1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)-pyrrolo[3,2,1 jk][1,4]benzodiazepine or a pharmaceutically acceptable salt or solvate thereof.

L'invention porte sur un procédé et un médicament pour traiter une leucémie de lignée mixte; une leucémie de lignée mixte associée à une translocation; une leucémie myélogène aiguë à base d'une leucémie de lignée mixte associée à une translocation; une leucémie lymphoïde aiguë à base d'une leucémie de lignée mixte associée à une translocation; un trouble myéloprolifératif chronique non à base d'une leucémie de lignée mixte (MLL) ou une leucémie lymphoïde aiguë non à base de MLL, l'agent actif utilisé étant l'inhibiteur de GSK-3 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tétrahydro-2-(1-pipéridinylcarbonyl)-pyrrolo[3,2,1-jk][1,4] benzodiazépine ou un sel ou solvate pharmaceutiquement acceptable de cette benzodiazépine.

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