C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/240.2
C07D 243/24 (2006.01) C07D 403/12 (2006.01)
Patent
CA 1163266
ABSTRACT The novel benzodiazepine derivatives of general formula Image I wherein R1 signifies lower alkyl, lower hydroxyalkyl or lower dialkylaminoalkyl, R2 and R3 each signify lower alkyl, R4 signifies halogen, R5, R7 and R8 each signify hydrogen or halogen and R6 signifies nitro, amino, lower alkylamino, lower dialkylamino or a group of the formula H2N-C(CH3)2-CO-NH-, R9R10N-CO-NH- or Image ABSTRACT: and either R9 signifies hydrogen or lower alkyl and R10 signifies lower alkyl or lower hydroxyalkyl or R9 and R10 together with the nitrogen atom signify a 3- to 7-membered heterocycle which, provided it is at least 5-membered, can contain as a ring member an oxygen or sulphur atom or a group of the formula = N-R in which R signifies hydrogen or lower alkyl, and their pharmaceutically acceptable acid addition salts possess aldosterone-antagonistic properties and are accordingly suitable for the control or prevention of heart failure, hepatic ascites, primary aldosteronism and idiopathic hypertension. They can be manufactured according to various methods and can be formulated in galenical administration forms.
380562
Branca Quirico
Fischli Albert E.
Szente Andre
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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