Benzodiazepine derivatives

Details Benzodiazepine derivatives Benzodiazepine derivatives

C - Chemistry, Metallurgy

07

D

260/240.3

C07D 403/02 (2006.01) C07D 243/24 (2006.01)

Patent

CA 1145333

RAN 4008/311 ABSTRACT The novel compounds of the formula Image I wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R represents a hydrogen or halogen atom, R4 represents a hydrogen atom or a group of the formula Image or Image A represents a lower alkylene group, X represents an oxygen or sulphur atom or a group of the formula ?N-R8, R5 represents a lower alkyl or lower haloalkyl group, R6 represents a hydrogen atom or a lower alkyl group, R7 represents a lower alkyl group and R8 represents a hydrogen atom or a lower alkyl or lower hydroxyalkyl group, and their pharmaceutically acceptable acid addition salts have aldosterone-antagonistic properties and are accordingly suitable for the control or prevention of heart failure, hepatic ascites, primary aldosteronism and idiopathic hypertension. They can be manufactured according to various methods starting from partially novel starting materials and they can be brought into a galenical administration form.

365868

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