C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/239.3
C07D 487/04 (2006.01) C07D 243/24 (2006.01)
Patent
CA 1152066
RAN 4008/310 ABSTRACT The novel compounds of the formula Image I wherein R1 represents a hydrogen atom or a lower alkyl group, R2 and R3 each represent a hydrogen atom or a lower alkyl group, R4 represents a halogen atom and either R5 represents a hydrogen atom or a lower alkyl group and R6 represents a lower alkyl or lower hydroxy- alkyl group or R5 and R6 together with the nitrogen atom to which they are attached represent a 3-membered to 7-membered heterocycle, and their pharmaceutically acceptable acid addition salts have aldosterone-antagonistic properties and are therefore suitable for the control or prevention of heart failure, hepatic ascites, primary aldosteronism and idiopathic hypertension. They can be manufactured according to various methods starting from partially novel starting materials and can be brought into galenical administration forms.
364874
Branca Quirico
Fischli Albert E.
Szente Andre
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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