Benzodiazepine derivatives

Details Benzodiazepine derivatives Benzodiazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/55 (2006.01) C07D 243/14 (2006.01) C07D 243/24 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2130196

2130196 9319052 PCTABS00025 Compounds of formula (I), and salts and prodrugs thereof. In that said formula, R1 represents certain optionally substitued alkyl or C3-7cycloalkyl; R2 represents (II) or (III), where m is 0, 1, 2 or 3, R9 is H or C1-6alkyl, R10 is imidazolyl, triazolyl or tetrazolyl, and R11 is H, C1-6alkyl or halo; R3 is C1-6alkyl, halo or NR6R7; R4 is C1-7alkyl, C3-10cycloalkyl, C3-10cycloalkylC1-4alkyl, C6-10bicycloalkyl, optionally substituted aryl, or NR12R13; R5 is H or C1-4alkyl; n is 0, 1, 2 or 3; are CCK and/or gastrin antagonists useful in therapy.

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