Benzodiazepine derivatives

Details Benzodiazepine derivatives Benzodiazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/00 (2006.01) A61K 31/55 (2006.01) C07D 221/24 (2006.01) C07D 243/14 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/00 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/02 (2006.01) C07D 453/06 (2006.01) C07D 471/02 (2006.01) C07D 487/08 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2140009

Compounds of formula (I), and salts and prodrugs thereof, wherein R1 represents H, optionally substituted C1-6alkyl or C3-7cycloalkyl; R2 is NHR12 or (CH2)sR13 where s is 0, 1 or 2; R3 represents C1-6alkyl, halo or NR6R7; R4 and R5 are H, C1-12alkyl optionally substituted by NR9R9' or an azacyclic or azabicyclic group, optionally substituted C4-9cycloalkyl, C4-9cycloalkylC1-4alkyl, aryl, arylC1-6alkyl or azacyclic or azabicyclic groups, or R4 and R5 together form the residue of an optionally substituted azacyclic or azabicyclic ring system; x is 0, 1, 2 or 3; R12 is optionally substituted phenyl or pyridyl; R13 represents a group (A) wherein R14 is H or C1-6alkyl; R15 is H, C1-6alkyl, halo or NR6R7; and the dotted line is an op- tional covalent bond; are CCK and/or gastrin antagonists useful in therapy.

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