Benzodiazepine derivatives for imaging thrombi

Details Benzodiazepine derivatives for imaging thrombi Benzodiazepine derivatives for imaging thrombi

A - Human Necessities

61

K

A61K 51/04 (2006.01) C07D 243/24 (2006.01)

Patent

CA 2372171

The invention provides compounds comprising glycoprotein IIb/IIIa receptor- binding benzodiazepine derivatives covalently linked to metal ion chelators. The compounds of the invention may be labeled with a radionuclide such as 99mTc and used to image thrombi.

Cette invention concerne des composée renfermant des dérivés des benzodiazépines qui se lient à la glycoprotéine IIb/au récepteur IIIa et qui sont unis par liaison covalente à des chélateurs d'ions métalliques. Les composés selon l'invention peuvent être marqués au moyen d'un radionucléide tel que ?99m¿Tc et permettent de visualiser des thrombus.

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