Benzodiazepines

Details Benzodiazepines Benzodiazepines

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2050858

RAN 4430/45 Abstract Benzodiazepines of formula Image wherein X is N(R,R1), OR4 or SR5, R and R1 are N(R2,R3) or substituted lower alkyl or an optionally substituted C3-C7-cycloalkyl, aryl, aralkyl or C2-C6-aliphatic hydrocarbon group, this aliphatic group having one or more double or triple bond, or one of R and R1 is hydrogen, or N(R,R1) is an optionally substitued heterocycle with one or more heteroatoms, R2 and R3 are H, lower alkyl, aryl or aralkyl, R4 is lower alkyl or has one of the meanings of R or R1 with the exception of H and of N(R2,R3), R5 is H or lower alkyl or has one of the meanings of R or R1 with the exception of N(R2,R3), Y and Z are H, NO2, N(R2,R3), halogen, CF3, OH, CN or lower alkyl or alkoxy, and A, B and C are H, CH3, C2H5, F or C1, and pharmaceutically acceptable salts thereof are useful as medicaments especially for the treatment or prophylaxis of viral infections, particularly ofretroviral infections, such as HIV 1 and/or HIV 2 infections, or for protecting cells against such injections.

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