C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/02 (2006.01) C07K 5/103 (2006.01) C07K 5/11 (2006.01) C07K 14/045 (2006.01) C07K 14/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2335102
The present invention relates to 1,4-benzodiazepines or 1,4-benzothiazepines derivatized with a peptide that can inhibit the interaction between annexin and annexin binding proteins. In particular, the present invention relates to 1,4-benzodiazepines or 1,4-benzothiazepines derivatives that can inhibit the interaction between annexin and viral proteins that bind annexins such as the HBaAg protein of HBV, glycoprotein B of the cytomegalovirus or any annexin binding protein from the influenza virus. These 1,4-benzodiazepines or 1,4- benzothiazepines derivates can be used to prevent or treat diseases in which interactions between annexin family members and annexin binding proteins are involved such as HBV and/or HBV infections, cytomegalovirus infections or influenza virus infections. The invention also relates to annexin binding epitopes from HBsAg and their use in the treatment of viral infections.
La présente invention concerne des 1,4-benzodiazépines ou 1,4-benzothiazépines dérivatisées avec un peptide et capables de bloquer l'interaction entre l'annexine et les protéines de liaison avec l'annexine. L'invention concerne plus particulièrement des dérivés 1,4-benzodiazépines ou 1,4-benzothiazépines capables de bloquer l'interaction entre l'annexine et des protéines virales de liaison avec les annexines telles que HBsAg du HBV, la glycoprotéine B du cytomégalovirus ou toute protéine de liaison avec l'annexine provenant du virus de la grippe. Ces dérivés 1,4-benzodiazépines ou 1,4-benzothiazépines conviennent pour le traitement préventif ou curatif d'affections dans lesquelles interviennent des interactions entre des éléments de la famille des annexines et des protéines constructrices de l'annexine, et notamment dans le cas des infections par HBV et/ou HDV, des infections par cytomégalovirus ou des infections par un virus de la grippe.
Depla Erik
Maertens Geert
Moereels Henri
Innogenetics N.v.
Smart & Biggar
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