Benzodiazepines, processes for their preparation and their use

Details Benzodiazepines, processes for their preparation and their use Benzodiazepines, processes for their preparation and their use

C - Chemistry, Metallurgy

07

D

167/210, 260/240

C07D 471/10 (2006.01) A61K 31/55 (2006.01) C07D 487/10 (2006.01)

Patent

CA 1249269

ABSTRACT The present invention relates to novel benzodiazepines of formula I, or pharmaceutically acceptable acid addition salts thereof, Image I in which R represents H, saturated or unsaturated, straight-chain, branched or cyclic alkyl, unsubstituted aralkyl or aralkyl which is optionally substituted in the aromatic part, unsubstituted or optionally substituted aryl or heteroaryl, R1 represents H, R2, R3 and R4 independently of one another represent H, alkyl or aralkyl which is unsubstituted or optionally substituted in the aromatic part, or, wherein R1 and R2 can also jointly form a bond, R5 and R6 independently of one another represent H, halogen, nitro, cyano, trifluoromethyl, lower alkyl or lower alkoxy and n represents an integer from 1 to 3, processes for their preparation and their use in combating diseases, in particular for the treatment of cerebral disorders caused by old age and for the treatment of disorders in learning and memory and amnesia.

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