Benzodiazoncine method

C - Chemistry – Metallurgy – 07 – D

Patent

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260/237.75

C07D 245/06 (2006.01) C07D 209/66 (2006.01) C07D 303/36 (2006.01)

Patent

CA 1122980

ABSTRACT OF THE DISCLOSURE A method for producing 3-hydroxy-6-phenyl-1,2,3,4- tetrahydro-1,5-benzodiazocines corresponding to the formula: Image and pharmaceutically acceptable acid-addition salts thereof, wherein R represents a hydrogen atom or a methyl group, R1 represents a phenyl group, a 2-halo-phenyl group or a 2-trifluoromethyl-phenyl group, and R2 represents a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group. In such method 2-aminobenzophenones corresponding to the formula: Image wherein R, R1 and R2 have the meanings given above, or addition salts thereof, are cyclized at an elevated temperature in the presence of an inert organic solvent.

323078

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