Benzodioxole derivatives

Details Benzodioxole derivatives Benzodioxole derivatives

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2058254

A B S T R A C T BENZODIOXOLE DERIVATIVES The invention concerns a benzodioxole derivative of the formula I Image I wherein Ar1 is an optionally substituted 9- or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; R1 is (1-6C)alkyl, (3-6C)alkenyl or (3-6C)alkynyl; and R2 and R3 together form a group of the formula -A1-X-A2- which, together with the carbon atom to which A1 and A2 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A1 and A2 is (1-3C)alkylene and X is oxy, thio, sulphinyl or sulphonyl, and which ring may bear one or two substituents; or a pharmaceutically-acceptable salt thereof; which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease.

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