C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/351.1, 260/3
C07D 317/62 (2006.01) C07D 317/46 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 1223874
- 1 - Case 4-14161/+ Novel benzodioxole derivatives, processes for the manufacture thereof and corresponding pharmaceutical compositions. Abstract The invention relates to novel benzodioxole derivatives of the general formula I Image (I), in which R1 represents an unsubstituted or substituted, aliphatic, aromatic or heteroaromatic radical, alk represents an alkylene, alkenylene or alkylidene radical having a maximum of 5 carbon atoms, n1 represents 0, 1 or 2 n2 represents 0 or 1, R2, R3 and R4 each represents, independently of the others, hydrogen, lower alkyl, lower - 2 - alkoxy or halogen, and A represents the radical -0-R5, wherein R5 represents hydrogen or an unsubstituted or substituted, aliphatic or araliphatic hydrocarbon radical, or A represents the radical Image in which either R6 and R7 each represents, independently of the other, hydrogen or lower alkyl, or R6 and R7 are bonded to one another and, together with the adjacent nitrogen atom, represent optionally lower alkyl- substituted tetra- to hexa-methylene- imino, 4-morpholinyl or 1H-tetrazol-1-yl, such as, for example, 5-methyl-6- phenylsulphonyl-1,3-benzodioxole-2- carboxylic acid. The invention relates also to salts of compounds of the general formula I in which A represents OR5 wherein R5 represents hydrogen, with bases, and to acid addition salts of compounds of the general formula I in which the radical R1 has a basic character and to processes for the manufacture of the above compounds and the salts thereof and to pharmaceutical compositions containing them. These novel substances have diuretic and supplementary uricosuric action and may be used, preferably in the form of appropriate pharmaceutical compositions, for the treatment of oedema and hyper- tension.
439384
Ballenegger Marc E.
Zbinden Paul
Fetherstonhaugh & Co.
Novartis Ag
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