Benzofluorene compounds, intermediates, compositions, and...

Details Benzofluorene compounds, intermediates, compositions, and... Benzofluorene compounds, intermediates, compositions, and...

C - Chemistry, Metallurgy

07

D

C07D 295/088 (2006.01) A61K 31/075 (2006.01) A61K 31/135 (2006.01) A61K 31/21 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07C 43/23 (2006.01) C07C 69/035 (2006.01) C07C 217/20 (2006.01) C07C 309/65 (2006.01) C07D 207/06 (2006.01) C07D 295/092 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2214935

The present invention provides compounds of formula I Image wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCO(C1-C6 alkyl), -OCOO(C1-C6 alkyl), -OCOAr, -OCOOAr, or -OSO2(C2-C6 alkyl); R2 is -OH, -O(C1-C4 alkyl), -OCO(C1-C6 alkyl), - OCOO(C1-C6 alkyl), -OCOAr, -OCOOAr, or -OSO2(C2-C6 alkyl); R3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1- pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1- hexamethyleneimino; and n is 2 or 3; or a pharmaceutically acceptable salt or solvate thereof.

Composés de formule I Image , où R1 est -H, -OH, -O(alkyle C1-C4), -OCO(alkyle C1-C6), -OCOO(alkyle C1-C6), -OCOAr, -OCOOAr, ou -OSO2(alkyle C2-C6); R2 est -OH, -O(alkyle C1-C4), -OCO(alkyle C1-C6), - OCOO(alkyle C1-C6), -OCOAr, -OCOOAr ou -OSO2(alkyle C2-C6); R3 est un groupe 1-pipéridinyle, 1-pyrrolidinyle, méthyl-1-pyrrolidinyle, diméthyl-1-pyrrolidinyle, 4-morpholino, diméthylamino, diéthylamino, diisopropylamino ou 1-hexaméthylèneimino; n est 2 ou 3. Ou un de leurs sels ou produits de solvatation, acceptables en pharmacie.

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