Benzofuran and benzothiaphene compounds

Details Benzofuran and benzothiaphene compounds Benzofuran and benzothiaphene compounds

C - Chemistry, Metallurgy

07

D

260/328.2, 260/3

C07D 307/84 (2006.01) C07C 45/46 (2006.01) C07C 45/63 (2006.01) C07C 49/784 (2006.01) C07C 63/04 (2006.01) C07D 307/85 (2006.01) C07D 311/22 (2006.01) C07D 333/54 (2006.01) C07D 333/56 (2006.01) C07D 333/68 (2006.01) C07D 409/06 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1220480

ABSTRACT Compounds of formula (I): Image (I) wherein: Ar is phenyl optionally substituted in the o-, m- or p-position by C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, bromo, chloro or fluoro, pyrryl optionally N-substituted by C1-4 alkyl, 2-furyl or 2-thienyl either optionally substituted in the 3-, 4- or 5-position by methyl, chloro or bromo, or 3-furyl or 3-thienyl; X is oxygen, sulphur, sulphoxide or sulphone, Y is methylene, R1 and R3 are hydrogen or C1-4 alkyl, and R2 is hydrogen, C1-4 alkyl, fluoro, chloro or bromo, or X is methylene, Y is oxygen, R1 and R3 are both hydrogen, and R2 is hydrogen, fluoro, chloro or bromo; and R4 is hydrogen or C1-4 alkyl, or a salt thereof, have analgesic and/or anti-inflammatory activity.

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