Benzofuran derivative

Details Benzofuran derivative Benzofuran derivative

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/501 (2006.01) A61P 1/04 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2512280

A compound represented by the general formula (1): (wherein R1 represents optionally substituted alkyl or optionally substituted alkenyl; and R2 and R3 each represents hydrogen, alkyl, hydroxyalkyl, dihydroxyalkyl, or alkynyl, provided that R2 and R3 may form an optionally substituted, nitrogenous, saturated, heterocyclic group in cooperation with the adjacent nitrogen) and a medicinal composition containing the compound. The compound functions to inhibit the production of a tumor necrosis factor (TNF-.alpha.) and has satisfactory oral absorbability.

Cette invention concerne un composé représenté par la formule générale (1) (dans laquelle R?1¿ désigne alkyle éventuellement substitué ou alcényle éventuellement substitué ; et R?2¿ et R?3¿ désignent chacun hydrogène, alkyle, hydroxyalkyle, dihydroxyalkyl ou alkynyle, à condition que R?2¿ et R?3¿ puissent former un groupe hétérocyclique saturé, azoté, éventuellement substitué agissant de concert avec l'azote adjacent) ainsi qu'une composition médicinale contenant le composé. Ce composé sert à inhiber la production d'un facteur de nécrose tumorale (TNF-.alpha.) et présente une absorbabilité par voie orale satisfaisante.

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