Benzofuran derivatives

Details Benzofuran derivatives Benzofuran derivatives

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/415 (2006.01) A61K 31/535 (2006.01) C07B 59/00 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2068766

-94- ABSTRACT BENZOFURAN DERIVATIVES The invention provides compounds of the general formula (I): Image or a physiologically acceptable salt, solvate or metabolically labile ester thereof wherein R1 represents a hydrogen atom or a halogen atom or a group selected from C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, Cl-6alkoxy ,-cao, -CO2H or -COR; Ar represents the group Image ; R2 represents a group selected from C1-6alkyl, C2-6alkenyl, C1-6alkoxy or the group -NR13R14; R3 represents a group selected from -CO2H, -NHSO2CF3 or a C-linked tetrazolyl group; R4 and R5 which may be the same or different each independently represent a hydrogen atom or a halogen atom or a C1-6alkyl group; Het represents the group Image ; R6 represents a hydrogen atom or a group selected from C1-6alkyl, C2-6alkenyl, C1-6alkylthio, C1-6alkoxy, C3-7cycloalkyl or C3-7cycloalkylC1-4alkyl; - 95 - R7 represents a hydrogen atom or a halogen atom or a group selected from cyano, nitro, C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, -(CH2)mR9, -(CH2)nCOR10, -(CH2)pNR11COR12, C3-7cycloalkyl or C3-7cycloalkylC1-4alkyl; R8 represents a hydrogen atom or a halogen atom or a group selected from cyano, nitro, C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, -(CH2)mR9, -(CH2)nCOR10 or -(CH2)pNR11COR12; and R9, R10, R11, R12, R13 and R14 are a variety of groups and substituents; with the proviso that when R6 represents a hydrogen atom or a group selected from Cl-6alkyl, C2-6alkenyl or C1-6alkylthio, R7 represents a group selected from C3-7cycloalkyl or C3-7cycloalkylC1-4alkyl. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

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