C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/367.1
C07D 307/80 (2006.01) C07D 307/86 (2006.01)
Patent
CA 1089866
ABSTRACT OF THE DISCLOSURE A benzofuran derivative of the formula: Image (I) wherein R1 is hydrogen atom, a lower alkyl group or phenyl group, R is a lower alkyl group, and the substituted propoxy group is at the 3, 4, 5, 6, or 7 position of the benzofuran ring; and its pharmaceutically acceptable acid addition salt, a process for the preparation of the same and a pharmaceutical composition containing the same. The benzofuran derivative and its pharmaceutically accepta- ble acid addition salt possess a superior .beta.-adrenergic blocking activity and local anesthetic activity, and are useful for the prevention and treatment of heart disease, hypertension and hyperthyroidism.
257342
Hayashida Mitsuo
Ikemoto Masahiko
Ito Kiyoshi
Kimura Kazuhiko
Nagahara Michiko
Kakenyaku Kako Co. Ltd.
Osler Hoskin & Harcourt Llp
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