Benzofuran derivatives, processes for preparing the same and...

Details Benzofuran derivatives, processes for preparing the same and... Benzofuran derivatives, processes for preparing the same and...

C - Chemistry, Metallurgy

07

D

167/223, 260/266

C07D 405/12 (2006.01) A61K 31/495 (2006.01) G11B 23/02 (2006.01)

Patent

CA 1243030

Abstruct of the Disclosure A [2-hydroxy-3-(4-phenylpiperazinyl)propoxy] benzofuran derivative having the formula (I): Image ( I ) wherein X is acetyl, carbamoyl, cyano, a lower alkoxy- carbonyl, carboxyl or 1-hydroxyethyl group, R is hydrogen atom, a lower alkoxy group, a lower alkyl group or a halogen atom; R is attached to an arbitrary position of ortho-position, meta-position and para-position to N- phenyl group, and a group having the formula: Image is attached to an arbitrary position of 4, 5, 6 and 7 positions to benzofuran ring or the salt thereof, a process for preparing the same and an antihypertensive agent containing the same as an effective component. The benzofuran derivative has a strong .alpha.-adrenergic blockade effect and calcium antagonistic effect with a more decreased side-effect.

477031

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