C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/343 (2006.01) A61K 31/357 (2006.01) A61K 31/4525 (2006.01) A61K 31/4745 (2006.01) A61K 31/496 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) C07D 307/87 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2353618
The present invention relates to benzofuran derivatives having general Formula (I). A is selected from (1), (2), (3), (4) wherein: Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6- alkyl-Aryl, or C1-6-alkyl-O-Aryl; D is a spacer group selected from branched or straight chain C1-6-alkylene, C2-6-alkenylene and C2-6-alkynylene; its enantiomers, and pharmaceutically acceptable acid addition salt thereof. The compounds are potently binding to the 5-HT1A receptor.
L'invention concerne des dérivés de benzofurane de formule (I), dans laquelle A est sélectionné dans les groupes (1), (2), (3), (4) dans lesquels Z désigne O ou S; s désigne 0 ou 1; q désigne 0 ou 1; R?4¿ désigne un hydrogène, C¿1-6?-alkyle, C¿2-6?-alcényle, C¿2-6?-alkynyle, C¿1-6?-alkyl-aryle ou C¿1-6?-alkyl-O-aryle; D désigne un groupe d'espacement sélectionné dans une chaîne ramifiée ou droite C¿1-6?-alkylène, C¿2-6?-alcénylène et C¿2-6?-alkynylène; leurs énantiomères et leur sel d'addition acide pharmaceutiquement acceptable. Les composés sont fortement liés au récepteur 5-HT¿1A?.
Andersen Kim
Bogeso Klaus Peter
Dancer Robert
Pedersen Henrik
Rottlander Mario
H. Lundbeck A/s
Robic
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