Benzofuran inhibitors of factor viia

Details Benzofuran inhibitors of factor viia Benzofuran inhibitors of factor viia

C - Chemistry, Metallurgy

07

D

C07D 307/82 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/443 (2006.01) A61P 7/02 (2006.01) C07D 307/83 (2006.01) C07D 307/86 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2525713

Compounds of Formula (I): are useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein and have improved pharmacokinetic properties. These compounds may be used in methods of preventing and/or treating clotting disorders.

L'invention concerne des composés de la formule I utiles pour inhiber les enzymes de la sérine protéase, tels que TF/facteur VIIa, facteur Xa, la thrombine et la kallikréine et ayant des propriétés pharmacocinétiques améliorées. Ces composés peuvent être utilisés dans des procédés de prévention et/ou de traitement de troubles de la coagulation.

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