Benzofurane, benzothiophene, benzothiazol derivatives as fxr...

C - Chemistry – Metallurgy – 07 – D

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C07D 307/85 (2006.01) A61K 31/343 (2006.01) A61P 3/00 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2721591

The present invention relates to compounds of formula (I) wherein the substituents are as defined in the claims, in-cluding pharmaceutical compositions thereof and for their use in the treatment and/or prevention and/or amelioration of one or more symptoms of disease or disorders related to the activity of FXR. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).

La présente invention concerne des composés de formule (I), dans laquelle les substituants sont tels que définis dans les revendications, ainsi que leurs compositions pharmaceutiques et leur utilisation pour le traitement et/ou la prévention et/ou lamélioration dun ou de plusieurs symptômes de maladies ou de troubles associés à lactivité de FXR. Linvention concerne également des intermédiaires et un procédé de préparation de composés de formule (I).

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