Benzofurazan compounds which enhance ampa receptor activity

C - Chemistry – Metallurgy – 07 – D

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C07D 413/06 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 25/28 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2279319

Compounds of general structural formula (I) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, such as memory impairment, in which AMPA receptors, or synapses utilizing these receptors, are reduced in numbers or efficiency. They may also be used to enhance excitatory synaptic activity in order to restore an imbalance between brain subregions, as in treatment of schizophrenia or schizophreniform behavior.

La présente invention concerne des composés représentés par la formule structurelle générale (I) et qui font preuve d'une aptitude à renforcer l'activité du récepteur AMPA. Ces composés conviennent à des fins thérapeutiques et notamment pour l'apprentissage de comportements liés aux récepteurs de l'AMPA, et pour le traitement d'états tels que les déficiences de la mémoire dans lesquelles les récepteurs de l'AMPA, ou les synapses utilisant ces récepteurs, sont présents en nombre réduit ou font preuve d'une moindre efficacité. Ces composés permettent également d'augmenter l'activité excitatrice des synapses afin de rétablir un équilibre entre les sous-régions du cerveau, comme dans le cas du traitement de la schizophrénie ou des comportements schizophréniformes.

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