Benzofuryl derivatives and their use

Details Benzofuryl derivatives and their use Benzofuryl derivatives and their use

C - Chemistry, Metallurgy

07

D

C07D 307/85 (2006.01) A61K 31/34 (2006.01) A61K 31/343 (2006.01) C07D 307/86 (2006.01)

Patent

CA 2253547

The invention is concerned with the use of compounds of general formula (I) wherein R1-R4 signify hydrogen, halogen, lower-alkyl, lower-alkoxy, aryl, benzyloxy, lower-alkoxy-lower-alkyl, lower-alkyl- sulphanyl, lower-alkyl-sulphanyl-lower-alkyl or R1 and R2 together signify the group -O-(CH2)2- or -(CH2)2-O- and R5 signifies hydrogen or hydroxy, as well as their pharmaceutically acceptable salts in the control or prevention of illnesses or disorders of the central nervous system such as migraine, schizophrenia, anxiety states, sleep disorders, anorexia, Alzheimer's disease, addictions (alcohol, nicotine, benzodi- azepine, cocaine, etc.), as well as disorders which result from damage to the head/brain or to the spinal column/bone marrow and, respectively, for the production of corresponding medicaments.

L'invention se rapporte à des composés représentés par la formule générale (I) et à des sels pharmaceutiquement acceptables de ces composés. Dans la formule (I) R<1>, R<2>, R<3> et R<4> sont hydrogène, halogène, alkyle inférieur, alcoxy inférieur, aryle, benzyloxy, alcoxy inférieur-alkyle inférieur, alkyle inférieur-sulphanyle, alkyle inférieur-sulphanyle-alkyle inférieur ou bien R<1> et R<2> représentent ensemble le groupe -O-(CH2)2 ou -(CH2)2-O- et R<5> est hydrogène ou hydroxy. L'invention concerne en particulier l'utilisation de ces composés et de leurs sels pour le traitement ou la prévention de maladies ou de troubles du système nerveux central tels que migraine, schizophrénie, états d'anxiété, troubles du sommeil, anorexie, maladie d'Alzheimer, dépendances à certaines drogues (alcool, nicotine, benzodiazépine, cocaïne, etc.) ainsi que des troubles résultant de blessures à la tête/au cerveau ou à la colonne vertébrale/ à la moelle épinière. L'invention se rapporte à la fabrication de médicaments destinés à ces maladies respectives.

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