Benzofurylpyrone derivatives

Details Benzofurylpyrone derivatives Benzofurylpyrone derivatives

C - Chemistry, Metallurgy

07

D

C07D 407/04 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2323456

Benzofuryl-.alpha.-pyrone derivatives represented by general formula (I) or salts thereof wherein R1 represents hydrogen or C1-5 alkyl; R2 represents hydrogen, -CO-R5 or SO2R6; R3 represents hydrogen, C1-5 alkyl, etc.; and R4 is a substituent of a definite structure attached to the 4-, 5-, 6- or 7-position of the benzofuran ring. These compounds are useful as remedies for hyperglyceridemia, lipid metabolism improving agents, preventives/remedies for arteriosclerosis, etc.

L'invention concerne des dérivés de benzofuryl-.alpha.-pyrone représentés par la formule générale (I), et des sels de ceux-ci. Dans la formule, R?1¿ est hydrogène ou alkyle en C¿1-5?; R?2¿ est hydrogène, -CO-R?5¿ ou -SO¿2?R?6¿; R?3¿ est hydrogène alkyle en C¿1-5?, etc.; et R?4¿ est un substituant d'une structure définie, fixée à la position 4, 5, 6 ou 7 du noyau benzofurane. Ces composés sont utiles comme remèdes contre l'hyperglycéridémie, comme agents améliorant le métabolisme des lipides, et pour prévenir/traiter l'artériosclérose, etc.

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