C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2489466
The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
L'invention concerne des composés de formule (I) et des promédicaments ou leurs métabolites, ou des sels ou des solvates pharmaceutiquement acceptables des composés, des promédicaments et des métabolites. Dans cette formule, Z, Y, R?11¿ et R?14¿, R?15¿, R?16¿, et R?17¿ sont définis dans la description. L'invention concerne également des compositions pharmaceutiques contenant les composés de formule (I) et des méthodes de traitement des troubles d'hyperprolifération chez un mammifère par administration des composés de formule (I).
Collins Michael Raymond
Cripps Stephan James
Deal Judith Gail
He Mingying
Kania Robert Steven
Pfizer Inc.
Smart & Biggar
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