C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/55 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61K 31/192 (2006.01) A61K 31/277 (2006.01) A61K 31/381 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/44 (2006.01) A61K 31/4406 (2006.01) A61K 31/47 (2006.01) A61P 1/02 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 21/02 (2006.01) A61P
Patent
CA 2419722
Benzoic acid derivatives represented by the following general formula (I) and nontoxic salts thereof wherein R1 represents COOH, COOR6, etc.; A and B each represents a carbon ring or a heterocycle; R2 represents alkyl, alkenyl, alkynyl, etc.; R4 represents alkyl, cycloalkyl, etc.; and R5 represents a carbon ring or a heterocycle. The compounds represented by the general formula (I) strongly bind to PGE2 receptors, in particular, subtypes EP3 and/or EP4 and exert an antagonism, which makes them useful in preventing and/or treating diseases such as pain, allergy, Alzheimer and cancer.
L'invention concerne des dérivés d'acide benzoïque représentés par la formule générale (I), ainsi que des sels non toxiques de ces derniers, formule dans laquelle R1 représente COOH, COOR6, etc. ; A et B représentent chacun un noyau de carbone ou un hétérocycle, R2 représente alkyle, alcényle, alcynyle, etc. ; R4 représente alkyle, cycloalkyle, etc. ; et R5 représente un noyau de carbone ou un hétérocycle. Les composés représentés par la formule générale (I) se lient fortement à des récepteurs PGE2, notamment des sous-types EP3 et/ou EP4, et exercent un antagonisme, ce qui les rend utiles dans la prévention et/ou le traitement de conditions, telles que la douleur, les allergies, la maladie d'Alzheimer et le cancer.
Asada Masaki
Kobayashi Kaoru
Narita Masami
Ogawa Mikio
Tani Kousuke
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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