Benzoic acid derivatives and their use as ppar receptor...

Details Benzoic acid derivatives and their use as ppar receptor... Benzoic acid derivatives and their use as ppar receptor...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/395 (2006.01) A61K 31/404 (2006.01) A61K 31/4439 (2006.01) A61K 31/4704 (2006.01) A61K 31/4709 (2006.01) A61P 43/00 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 215/20 (2006.01) C07D 215/22 (2006.01) C07D 215/227 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2380775

The present invention relates to the use of certain benzoic acid derivatives of formula (I), where the substituents are as defined in the specification, which act as peroxisome proliferator activated receptor (PPAR) agonists, in particular gamma receptors (PPAR.gamma.), and so are useful in the treatment of states of insulin resistance, including type 2 diabetes mellitus.

L'invention concerne l'utilisation de certains dérivés de l acide benzoïque de formule (I), dans laquelle les substituants sont tels que définis dans la spécification, qui agissent comme des agonistes de récepteur activé de la prolifération des peroxisomes (PPAR), en particulier les récepteurs gamma PPAR.gamma.), et servent donc à traiter les états de résistance à l'insuline, y compris le diabète de type 2.

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