C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61P 17/04 (2006.01) A61P 29/00 (2006.01) C07D 235/04 (2006.01)
Patent
CA 2596013
Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.
La présente invention porte sur de nouveaux dérivés benzoimidazole agissant comme antagonistes du récepteur 1 de vanilloïde et une composition pharmaceutique les contenant. Ces dérivés sont utilisés pour prévenir ou traiter la douleur, la douleur aiguë, la douleur chronique, la douleur névropathique, la douleur postopératoire, les migraines, l'arthralgie, la neuropathie, la lésion nerveuse, la neuropathie diabétique, la maladie neurologique, la neurodermatite, des accidents vasculaires cérébraux, l'hypersensibilité de la vessie, le syndrome du côlon irritable, les troubles respiratoires tels que l'asthme ou la maladie pulmonaire obstructive chronique, les brûlures, le psoriasis, le prurit, les vomissements, l'irritation de la peau, des yeux et des membranes muqueuses, les ulcères gastro-duodénaux, les maladies intestinales inflammatoires et les maladies inflammatoires.
Hyun Hyae Jung
Kim In Woo
Kim Ji Duck
Yoon Hong Chul
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Daewoong Pharmaceutical Co. Ltd.
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