Benzoimidazole derivatives useful as antiproliferative agents

Details Benzoimidazole derivatives useful as antiproliferative agents Benzoimidazole derivatives useful as antiproliferative agents

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07H 15/26 (2006.01)

Patent

CA 2582479

The invention relates to substantially pure compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R, R1, R2, R3,R4, and R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (1) and methods of treating abnormal cell growth, such as cancer, in mammals by administering such pharmaceutical formulations.

La présente invention se rapporte à des composés sensiblement purs représentés par la formule (I) et à des sels pharmaceutiquement acceptables, à des promédicaments et à des solvates de ceux-ci, R, R1, R2, R3,R4 et R5 étant tels que définis dans le descriptif de l'invention. L'invention a également trait à des compositions pharmaceutiques contenant les composés représentés par la formule (I), ainsi qu'à des méthodes permettant de traiter la croissance cellulaire anormale, telle que dans un cancer, chez des mammifères, par l'administration de telles compositions pharmaceutiques.

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