Benzoimidazole derivatives useful as antiproliferative agents

Details Benzoimidazole derivatives useful as antiproliferative agents Benzoimidazole derivatives useful as antiproliferative agents

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 491/10 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2392973

The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R7, R8, R9, R10, and R11 are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).

La présente invention concerne des composés représentés par la formule (1) et des sels, des promédicaments et des solvates pharmaceutiquement acceptables de ceux-ci. Dans cette formule R<1>, R<7>, R<8>, R<9>, R<10>, et R<11> sont tels que définis dans les spécifications. Cette invention concerne aussi des techniques de traitement de dysfonctionnements dans la croissance cellulaire chez les mammifères, tel que le cancer, par administration de ces composés représentés par la formule (1), ainsi que des compositions pharmaceutiques contenant ces composés, permettant de traiter ces dysfonctionnements. Cette invention concerne enfin des techniques de préparation de ces composés représentés par la formule (1).

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