Benzomorpholine derivatives and methods of use

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 413/14 (2006.01) A61K 31/536 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2703257

Selected benzomorpholine compounds are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

La présente invention concerne des composés de benzomorpholine efficaces dans la prophylaxie et le traitement de maladies, telles que des maladies induites par le VEGF. L'invention concerne également de nouveaux composés, analogues et promédicaments, ainsi que des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques et des procédés de prophylaxie et de traitement de maladies et d'autres maladies ou états impliquant le cancer et analogue. La présente invention porte en outre sur des procédés de réalisation de tels composés, ainsi que sur des intermédiaires utiles dans de tels procédés.

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