Benzonitrile derivatives to treat musculoskeletal frailty

Details Benzonitrile derivatives to treat musculoskeletal frailty Benzonitrile derivatives to treat musculoskeletal frailty

C - Chemistry, Metallurgy

07

C

C07C 255/58 (2006.01) A61K 31/277 (2006.01) A61K 31/401 (2006.01) A61K 31/451 (2006.01) A61K 31/55 (2006.01) C07D 207/08 (2006.01) C07D 211/22 (2006.01) C07D 295/14 (2006.01)

Patent

CA 2565544

This invention relates to novel amino substituted benzonitrile derivatives and to pharmaceutical compositions containing the novel amino substituted benzonitrile derivatives. This invention also relates to methods of treatment using amino substituted benzonitrile derivatives to prevent and/or restore age- related decline in muscle mass and strength, treat a wasting disease, treat a condition that prevents with low bone mass, increase muscle mass, increase lean body mass, decrease fat body mass, and treat bone fracture and muscle damage in mammals, including humans.

L'invention concerne des dérivés de benonitrile substitués par amino et des compositions pharmaceutiques renfermant ceux-ci. L'invention concerne également des méthodes de traitement mettant en oeuvre lesdits dérivés, aux fins de prévention et/ou de restauration du déclin lié à l'âge de la masse et de la force musculaires, de traitement de la maladie des avortons, de traitement d'un état empêchant une faible masse osseuse, d'augmentation de la masse musculaire, d'augmentation de la masse maigre, de diminution de la masse corporelle grasse et de traitement de fracture osseuse et de dommage musculaire chez des animaux, notamment les êtres humains.

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