Benzophenanthridine alkaloids for topical acne treatment

Details Benzophenanthridine alkaloids for topical acne treatment Benzophenanthridine alkaloids for topical acne treatment

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2062970

2062970 9100728 PCTABS00003 A method for topical treatment of P. acnes in mammals with a composition containing benzophenanthridine alkaloid and a skin penetration enhancer. Preferred alkaloids are selected from the group consisting of sanguinarine, chelerythrine, sanguilutine, sanguirubine, chelirubine and chelilutine. The penetration enhancer is selected from the group consisting of pyrrolidones, pyrroles, ethanol, propylene glycol, oleic acids, isopropyl myristate, 1-dodecylazacycloheptan-2-one, hexamethylene palmitamide, hexamethylene laurimide, dimethyl sulfoxide, dimethyl sulfone, N,N-dimethyl formamide, N,N-diethyl toluamide, caprolactam, aliphatic alcohols and aliphatic esters. The compositions may be in the form of liquids, lotions, gels, etc.

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